{"id":31,"date":"2026-02-06T11:02:35","date_gmt":"2026-02-06T02:02:35","guid":{"rendered":"http:\/\/sotoma-lab.com\/?page_id=31"},"modified":"2026-04-30T17:55:58","modified_gmt":"2026-04-30T08:55:58","slug":"resarch","status":"publish","type":"page","link":"https:\/\/sotoma-lab.com\/?page_id=31","title":{"rendered":"Research"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u6982\u8981\u3000(Research overview)<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u751f\u304d\u305f\u7d30\u80de\u306e\u7269\u7406\u5316\u5b66\u91cf\u3092\u89b3\u5bdf\u30fb\u8a08\u6e2c\u30fb\u64cd\u4f5c\u3059\u308b\u91cf\u5b50\u30bb\u30f3\u30b5\u306e\u958b\u767a\u3068\u5fdc\u7528\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"nanoparticle-design\">\uff11\uff09\u30ca\u30ce\u7c92\u5b50\u306e\u8a2d\u8a08\u30fb\u8868\u9762\u5316\u5b66\u4fee\u98fe\u30fb\u30d0\u30a4\u30aa\u5fdc\u7528<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ca\u30ce\u7c92\u5b50\u306f\uff0c\u30b5\u30a4\u30ba\u304c\u6570 nm\u301c\u6570\u5341 nm \u306e\u9818\u57df\u306b\u5c0f\u3055\u304f\u306a\u308b\u3053\u3068\u3067\uff0c\u30d0\u30eb\u30af\u6750\u6599\u3068\u306f\u7570\u306a\u308b\u5149\u5b66\u5fdc\u7b54\uff0c\u8868\u9762\u53cd\u5fdc\u6027\uff0c\u91cf\u5b50\u52b9\u679c\u306a\u3069\u3092\u793a\u3057\u307e\u3059\uff0e\u3053\u308c\u3089\u306e\u7279\u6027\u306f\uff0c\u7c92\u5b50\u306e\u30b5\u30a4\u30ba\u3084\u7d50\u6676\u69cb\u9020\uff0c\u6b20\u9665\uff0c\u8868\u9762\u72b6\u614b\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5909\u5316\u3059\u308b\u305f\u3081\uff0c\u30ca\u30ce\u7c92\u5b50\u306f\u7d30\u80de\u5185\u3084\u751f\u4f53\u5206\u5b50\u306e\u8fd1\u508d\u3067\u50cd\u304f\u6a5f\u80fd\u6027\u30d7\u30ed\u30fc\u30d6\u30fb\u30bb\u30f3\u30b5\u3068\u3057\u3066\u5927\u304d\u306a\u53ef\u80fd\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u3059\uff0e\u5f53\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u30c0\u30a4\u30e4\u30e2\u30f3\u30c9\uff0c\u70ad\u5316\u30b1\u30a4\u7d20\uff0c\u7a92\u5316\u30db\u30a6\u7d20\uff0c\u91d1\u30ca\u30ce\u7c92\u5b50\uff0c\u91d1\u30ca\u30ce\u30ed\u30c3\u30c9\uff0c\u78c1\u6027\u7c92\u5b50\uff0c\u91d1\u5c5e\u91cf\u5b50\u30c9\u30c3\u30c8\uff0c\u30ab\u30fc\u30dc\u30f3\u91cf\u5b50\u30c9\u30c3\u30c8\uff0c\u30b7\u30ea\u30ab\u306a\u3069\uff0c\u591a\u69d8\u306a\u30ca\u30ce\u7c92\u5b50\u306e\u8a2d\u8a08\u30fb\u5408\u6210\u304b\u3089\u8a55\u4fa1\uff0c\u5fdc\u7528\u5c55\u958b\u307e\u3067\u3092\u4e00\u8cab\u3057\u3066\u884c\u3063\u3066\u3044\u307e\u3059\uff0e\u7279\u306b\uff0c\u30ca\u30ce\u7c92\u5b50\u3092\u751f\u4f53\u74b0\u5883\u3067\u5b89\u5b9a\u306b\u6a5f\u80fd\u3055\u305b\u308b\u305f\u3081\uff0c\u30dd\u30ea\u30c9\u30fc\u30d1\u30df\u30f3\uff0c\u30dd\u30ea\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\uff0c\u8102\u8cea\u819c\uff0c\u30b7\u30ea\u30ab\u306a\u3069\u3092\u7528\u3044\u305f\u8868\u9762\u5316\u5b66\u4fee\u98fe\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\uff0e\u3053\u308c\u306b\u3088\u308a\uff0c\u5206\u6563\u5b89\u5b9a\u6027\u3084\u751f\u4f53\u9069\u5408\u6027\u3092\u9ad8\u3081\u308b\u3060\u3051\u3067\u306a\u304f\uff0c\u975e\u7279\u7570\u5438\u7740\u306e\u6291\u5236\u3084\u5206\u5b50\u6a19\u7684\u5316\u306a\u3069\uff0c\u76ee\u7684\u306b\u5fdc\u3058\u305f\u6a5f\u80fd\u3092\u4ed8\u4e0e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\uff0e\u307e\u305f\uff0c\u86cd\u5149\u6027\u30ca\u30ce\u30c0\u30a4\u30e4\u30e2\u30f3\u30c9\u3084\u70ad\u5316\u30b1\u30a4\u7d20\uff0c\u7a92\u5316\u30db\u30a6\u7d20\u306a\u3069\u306e\u6b20\u9665\u542b\u6709\u30ca\u30ce\u7c92\u5b50\u306f\uff0c\u5149\u3067\u8aad\u307f\u51fa\u305b\u308b\u91cf\u5b50\u72b6\u614b\u3092\u5185\u90e8\u306b\u6301\u3064\u305f\u3081\uff0c\u6b21\u4e16\u4ee3\u306e\u91cf\u5b50\u30bb\u30f3\u30b5\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\uff0e\u5f53\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u3053\u308c\u3089\u306e\u30ca\u30ce\u7c92\u5b50\u306e\u8868\u9762\u72b6\u614b\u3084\u5206\u6563\u6027\u3092\u5236\u5fa1\u3057\uff0c\u6e29\u5ea6\uff0c\u78c1\u5834\uff0c\u30e9\u30b8\u30ab\u30eb\uff0c\u7c92\u5b50\u306e\u904b\u52d5\u306a\u3069\uff0c\u7d30\u80de\u5185\u306e\u5fae\u5c0f\u306a\u7269\u7406\u5316\u5b66\u91cf\u3092\u8a08\u6e2c\u3059\u308b\u6280\u8853\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u307e\u3059\uff0e\u3055\u3089\u306b\uff0c\u30ab\u30fc\u30dc\u30f3\u91cf\u5b50\u30c9\u30c3\u30c8\u306e\u3088\u3046\u306a\u767a\u5149\u6027\u30ab\u30fc\u30dc\u30f3\u30ca\u30ce\u6750\u6599\u3092\u7528\u3044\u305f\u86cd\u5149\u30ca\u30ce\u6e29\u5ea6\u8a08\u306e\u958b\u767a\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\uff0e\u5408\u6210\u6761\u4ef6\u3084\u524d\u99c6\u4f53\u69cb\u9020\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067\uff0c\u767a\u5149\u6ce2\u9577\u3084\u6e29\u5ea6\u5fdc\u7b54\u6027\u3092\u8abf\u6574\u3057\uff0c\u86cd\u5149\u5f37\u5ea6\uff0c\u30ec\u30b7\u30aa\uff0c\u86cd\u5149\u5bff\u547d\u306a\u3069\u8907\u6570\u306e\u691c\u51fa\u30e2\u30fc\u30c9\u306b\u5bfe\u5fdc\u3057\u305f\u7d30\u80de\u5185\u6e29\u5ea6\u8a08\u6e2c\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\uff0e\u3053\u308c\u3089\u306e\u7814\u7a76\u3092\u901a\u3058\u3066\uff0c\u30ca\u30ce\u7c92\u5b50\u3092\u300c\u89b3\u308b\u305f\u3081\u306e\u30d7\u30ed\u30fc\u30d6\u300d\u304b\u3089\u300c\u6e2c\u308b\u305f\u3081\u306e\u30bb\u30f3\u30b5\u300d\u3078\u3068\u767a\u5c55\u3055\u305b\uff0c\u751f\u547d\u73fe\u8c61\u306e\u65b0\u3057\u3044\u7406\u89e3\u306b\u3064\u306a\u3052\u3066\u3044\u304d\u307e\u3059\uff0e<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"286\" height=\"282\" src=\"http:\/\/sotoma-lab.com\/wp-content\/uploads\/2026\/02\/image.png\" alt=\"\" class=\"wp-image-32\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbS. Sotoma, H. Abe, Y. Miyanoiri, T. Ohshima, and Y. Harada, \u201cHighly Dispersed 3C Silicon Carbide Nanoparticles with a Polydopamine\/Polyglycerol Shell for Versatile Functionalization,\u201d ACS Applied Materials &amp; Interfaces, 15, 21413\u201321424 (2023). <br>\u30fbS. Sotoma, F.-J. Hsieh, Y.-W. Chen, P.-C. Tsai, and H.-C. Chang, \u201cHighly Stable Lipid-Encapsulation of Fluorescent Nanodiamonds for Bioimaging Applications,\u201d Chemical Communications, 54, 1000\u20131003 (2018). <br>\u30fbS. Sotoma and Y. Harada, \u201cPolydopamine Coating as a Scaffold for Ring-Opening Chemistry To Functionalize Gold Nanoparticles,\u201d Langmuir, 35, 8357\u20138362 (2019). \u30fbS. Sotoma and Y. Harada, \u201cComposite Quantum Sensors Based on Fluorescent Nanodiamonds for Intracellular Controlled Heating in Living Cells,\u201d ACS Applied Nano Materials, 4, 3969\u20133976 (2021). <br>\u30fbS. Sotoma, K. Akagi, S. Hosokawa, R. Igarashi, H. Tochio, Y. Harada, and M. Shirakawa, \u201cComprehensive and Quantitative Analysis for Controlling the Physical\/Chemical States and Particle Properties of Nanodiamonds for Biological Applications,\u201d RSC Advances, 5, 13818\u201313827 (2015). <br><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"fluorescence-imaging\">\uff12\uff09\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30fb\u7d30\u80de\u5185\u52d5\u614b\u89e3\u6790<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306f\uff0c\u7d30\u80de\u5185\u3067\u8d77\u304d\u3066\u3044\u308b\u73fe\u8c61\u3092\u5149\u3068\u3057\u3066\u53ef\u8996\u5316\u3057\uff0c\u901a\u5e38\u306f\u898b\u3048\u306a\u3044\u5206\u5b50\u3084\u69cb\u9020\u306e\u5206\u5e03\u30fb\u52d5\u614b\u3092\u89b3\u5bdf\u3059\u308b\u6280\u8853\u3067\u3059\uff0e\u86cd\u5149\u8272\u7d20\u3084\u86cd\u5149\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\u308b\u3053\u3068\u3067\uff0c\u7279\u5b9a\u306e\u5206\u5b50\uff0c\u30aa\u30eb\u30ac\u30cd\u30e9\uff0c\u7d30\u80de\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u3092\u9078\u629e\u7684\u306b\u300c\u898b\u3048\u308b\u5316\u300d\u3067\u304d\uff0c\u751f\u7d30\u80de\u306e\u307e\u307e\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u305d\u306e\u5909\u5316\u3092\u8ffd\u8de1\u3067\u304d\u307e\u3059\uff0e\u3053\u306e\u6280\u8853\u306f\uff0c\u7d30\u80de\u5185\u3067\u5206\u5b50\u304c\u3069\u3053\u306b\u5b58\u5728\u3057\uff0c\u3069\u306e\u3088\u3046\u306b\u79fb\u52d5\u3057\uff0c\u3069\u306e\u3088\u3046\u306a\u523a\u6fc0\u306b\u5fdc\u7b54\u3059\u308b\u306e\u304b\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306e\u91cd\u8981\u306a\u624b\u6cd5\u3067\u3059\uff0e\u5f53\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u5149\u5b89\u5b9a\u6027\u3084\u74b0\u5883\u8010\u6027\u306b\u512a\u308c\u305f\u86cd\u5149\u30ca\u30ce\u6750\u6599\u3092\u8a2d\u8a08\u3057\uff0c\u7d30\u80de\u5185\u3084\u7d30\u80de\u819c\u4e0a\u306e\u5206\u5b50\u3092\u9ad8\u611f\u5ea6\u306b\u89b3\u5bdf\u3059\u308b\u305f\u3081\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u624b\u6cd5\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059\uff0e\u7279\u306b\uff0c\u86cd\u5149\u6027\u30ca\u30ce\u30c0\u30a4\u30e4\u30e2\u30f3\u30c9\u306f\uff0c\u5185\u90e8\u306b\u7a92\u7d20\uff0d\u7a7a\u5b54\u4e2d\u5fc3\u3092\u6301\u3064\u3053\u3068\u3067\uff0c\u975e\u5e38\u306b\u9ad8\u3044\u5149\u5b89\u5b9a\u6027\u3092\u793a\u3057\uff0c\u9577\u6642\u9593\u306e\u89b3\u5bdf\u306b\u9069\u3057\u305f\u86cd\u5149\u30d7\u30ed\u30fc\u30d6\u3068\u3057\u3066\u5229\u7528\u3067\u304d\u307e\u3059\uff0e\u5f93\u6765\u306e\u6709\u6a5f\u86cd\u5149\u8272\u7d20\u3084\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u306f\uff0c\u5149\u9000\u8272\u306b\u3088\u308a\u9577\u6642\u9593\u8ffd\u8de1\u304c\u96e3\u3057\u3044\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u86cd\u5149\u6027\u30ca\u30ce\u30c0\u30a4\u30e4\u30e2\u30f3\u30c9\u3092\u7528\u3044\u308b\u3053\u3068\u3067\uff0c\u7d30\u80de\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u7d30\u80de\u5185\u69cb\u9020\u306e\u52d5\u304d\u3092\u9577\u6642\u9593\u306b\u308f\u305f\u3063\u3066\u89b3\u5bdf\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\uff0e\u4e00\u65b9\u3067\uff0c\u86cd\u5149\u30ca\u30ce\u7c92\u5b50\u3092\u7d30\u80de\u5b9f\u9a13\u306b\u7528\u3044\u308b\u305f\u3081\u306b\u306f\uff0c\u5358\u306b\u660e\u308b\u304f\u5149\u308b\u3060\u3051\u3067\u306f\u4e0d\u5341\u5206\u3067\u3059\uff0e\u7c92\u5b50\u304c\u51dd\u96c6\u305b\u305a\uff0c\u751f\u4f53\u5206\u5b50\u306b\u975e\u7279\u7570\u7684\u306b\u5438\u7740\u305b\u305a\uff0c\u76ee\u7684\u306e\u5206\u5b50\u3084\u7d30\u80de\u69cb\u9020\u306b\u9078\u629e\u7684\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\uff0e\u305d\u3053\u3067\u5f53\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u30dd\u30ea\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u4fee\u98fe\uff0c\u8102\u8cea\u88ab\u8986\uff0c\u30af\u30ea\u30c3\u30af\u30b1\u30df\u30b9\u30c8\u30ea\u30fc\uff0c\u30bf\u30b0\u30b7\u30b9\u30c6\u30e0\u306a\u3069\u3092\u7d44\u307f\u5408\u308f\u305b\uff0c\u86cd\u5149\u30ca\u30ce\u7c92\u5b50\u306e\u8868\u9762\u3092\u7cbe\u5bc6\u306b\u8a2d\u8a08\u3057\u3066\u3044\u307e\u3059\uff0e\u3053\u308c\u306b\u3088\u308a\uff0c\u7d30\u80de\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u9078\u629e\u7684\u306b\u6a19\u8b58\u3057\u305f\u308a\uff0c\u751f\u7d30\u80de\u4e2d\u3067\u5206\u5b50\u306e\u52d5\u304d\u3092\u8ffd\u8de1\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\uff0e\u5b9f\u969b\u306b\uff0c\u86cd\u5149\u6027\u30ca\u30ce\u30c0\u30a4\u30e4\u30e2\u30f3\u30c9\u3092\u7528\u3044\u305f\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9078\u629e\u7684\u6a19\u8b58\u3084\uff0c\u9577\u6642\u9593\u306e\u5358\u4e00\u7c92\u5b50\u8ffd\u8de1\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u304d\u307e\u3057\u305f\uff0e\u3055\u3089\u306b\uff0c\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u300c\u898b\u308b\u300d\u305f\u3081\u306e\u6280\u8853\u306b\u3068\u3069\u3081\u305a\uff0c\u7d30\u80de\u5185\u306e\u7269\u7406\u5316\u5b66\u91cf\u3092\u300c\u6e2c\u308b\u300d\u305f\u3081\u306e\u6280\u8853\u3078\u3068\u767a\u5c55\u3055\u305b\u3066\u3044\u307e\u3059\uff0e\u4f8b\u3048\u3070\uff0c\u30ab\u30fc\u30dc\u30f3\u91cf\u5b50\u30c9\u30c3\u30c8\u3092\u7528\u3044\u305f\u86cd\u5149\u30ca\u30ce\u6e29\u5ea6\u8a08\u3067\u306f\uff0c\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u30ca\u30ce\u7c92\u5b50\u306e\u86cd\u5149\u5fdc\u7b54\u3092\u5229\u7528\u3057\u3066\uff0c\u5358\u4e00\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u6e29\u5ea6\u5909\u5316\u3092\u6e2c\u5b9a\u3067\u304d\u307e\u3059\uff0e\u86cd\u5149\u5f37\u5ea6\uff0c\u30ec\u30b7\u30aa\uff0c\u86cd\u5149\u5bff\u547d\u306a\u3069\uff0c\u8907\u6570\u306e\u691c\u51fa\u30e2\u30fc\u30c9\u3092\u4f7f\u3044\u5206\u3051\u308b\u3053\u3068\u3067\uff0c\u7d30\u80de\u5185\u74b0\u5883\u306e\u5f71\u97ff\u3092\u6291\u3048\u306a\u304c\u3089\uff0c\u3088\u308a\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u7d30\u80de\u5185\u8a08\u6e2c\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\uff0e\u3053\u306e\u3088\u3046\u306b\u5f53\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u86cd\u5149\u30ca\u30ce\u6750\u6599\u306e\u8a2d\u8a08\uff0c\u8868\u9762\u5316\u5b66\u4fee\u98fe\uff0c\u5206\u5b50\u6a19\u8b58\uff0c\u7d30\u80de\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\uff0c\u7269\u7406\u5316\u5b66\u91cf\u8a08\u6e2c\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\uff0c\u751f\u547d\u73fe\u8c61\u3092\u65b0\u3057\u3044\u8996\u70b9\u304b\u3089\u89b3\u5bdf\u3059\u308b\u6280\u8853\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u307e\u3059\uff0e\u7d30\u80de\u5185\u3067\u8d77\u3053\u308b\u5206\u5b50\u306e\u52d5\u304d\uff0c\u5c40\u5728\u5909\u5316\uff0c\u6e29\u5ea6\u5909\u5316\uff0c\u523a\u6fc0\u5fdc\u7b54\u306a\u3069\u3092\u53ef\u8996\u5316\u30fb\u8a08\u6e2c\u3059\u308b\u3053\u3068\u3067\uff0c\u3053\u308c\u307e\u3067\u898b\u3048\u306a\u304b\u3063\u305f\u7d30\u80de\u6a5f\u80fd\u306e\u7406\u89e3\u306b\u3064\u306a\u3052\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\uff0e<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"318\" height=\"318\" src=\"http:\/\/sotoma-lab.com\/wp-content\/uploads\/2026\/02\/image-1.png\" alt=\"\" class=\"wp-image-33\" srcset=\"https:\/\/sotoma-lab.com\/wp-content\/uploads\/2026\/02\/image-1.png 318w, https:\/\/sotoma-lab.com\/wp-content\/uploads\/2026\/02\/image-1-300x300.png 300w, https:\/\/sotoma-lab.com\/wp-content\/uploads\/2026\/02\/image-1-150x150.png 150w\" sizes=\"auto, (max-width: 318px) 100vw, 318px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbY. S. Kato, Y. Shimazaki, S. Chuma, K. Shiraya, Y. Nakane, T. Sugi, K. Okabe, Y. Harada, and S. Sotoma, \u201cFluorescent Thermometers Based on Carbon Quantum Dots with Various Detection Modes for Intracellular Temperature Measurement,\u201d Nano Letters (2025). <br>\u30fbS. Sotoma, F.-J. Hsieh, Y.-W. Chen, P.-C. Tsai, and H.-C. Chang, \u201cHighly Stable Lipid-Encapsulation of Fluorescent Nanodiamonds for Bioimaging Applications,\u201d Chemical Communications, 54, 1000\u20131003 (2018). <br>\u30fbF.-J. Hsieh, S. Sotoma, H.-H. Lin, C.-Y. Cheng, T.-Y. Yu, C.-L. Hsieh, C.-H. Lin, and H.-C. Chang, \u201cBioorthogonal Fluorescent Nanodiamonds for Continuous Long-Term Imaging and Tracking of Membrane Proteins,\u201d ACS Applied Materials &amp; Interfaces (2019). <br>\u30fbS. Sotoma, J. Iimura, R. Igarashi, K. M. Hirosawa, H. Ohnishi, S. Mizukami, K. Kikuchi, T. K. Fujiwara, M. Shirakawa, and H. Tochio, \u201cSelective Labeling of Proteins on Living Cell Membranes Using Fluorescent Nanodiamond Probes,\u201d Nanomaterials, 6, 56 (2016).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"quantum-sensing\">\uff13\uff09\u91cf\u5b50\u30bb\u30f3\u30b7\u30f3\u30b0\u30fb\u7d30\u80de\u5185\u7269\u7406\u5316\u5b66\u91cf\u8a08\u6e2c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6e29\u5ea6\u3084\u78c1\u5834\uff0c\u96fb\u5834\uff0c\u5316\u5b66\u74b0\u5883\u3068\u3044\u3063\u305f\u7269\u7406\u5316\u5b66\u91cf\u306f\uff0c\u751f\u547d\u73fe\u8c61\u3084\u6750\u6599\u6a5f\u80fd\u3092\u7406\u89e3\u3059\u308b\u3046\u3048\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\uff0e\u91cf\u5b50\u30bb\u30f3\u30b7\u30f3\u30b0\u3067\u306f\uff0c\u91cf\u5b50\u72b6\u614b\u304c\u5916\u90e8\u74b0\u5883\u306b\u654f\u611f\u306b\u5fdc\u7b54\u3059\u308b\u6027\u8cea\u3092\u5229\u7528\u3057\u3066\uff0c\u3053\u308c\u3089\u306e\u7269\u7406\u5316\u5b66\u91cf\u3092\u9ad8\u611f\u5ea6\u306b\u8a08\u6e2c\u3057\u307e\u3059\uff0e\u7279\u306b\uff0c\u30c0\u30a4\u30e4\u30e2\u30f3\u30c9\u4e2d\u306e\u7a92\u7d20\uff0d\u7a7a\u5b54\u4e2d\u5fc3\u306f\uff0c\u86cd\u5149\u3092\u767a\u3059\u308b\u3060\u3051\u3067\u306a\u304f\uff0c\u5149\u691c\u51fa\u78c1\u6c17\u5171\u9cf4\u3092\u901a\u3058\u3066\u30b9\u30d4\u30f3\u72b6\u614b\u3092\u8aad\u307f\u51fa\u305b\u308b\u305f\u3081\uff0c\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb\u306e\u6e29\u5ea6\u30bb\u30f3\u30b5\u3068\u3057\u3066\u5229\u7528\u3067\u304d\u307e\u3059\uff0e\u5f53\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u86cd\u5149\u6027\u30ca\u30ce\u30c0\u30a4\u30e4\u30e2\u30f3\u30c9\u3092\u751f\u7d30\u80de\u5185\u306b\u5c0e\u5165\u3057\uff0c\u7d30\u80de\u5185\u306e\u5fae\u5c0f\u7a7a\u9593\u306b\u304a\u3051\u308b\u6e29\u5ea6\u5909\u5316\u3084\u5c40\u6240\u74b0\u5883\u3092\u975e\u4fb5\u8972\u7684\u306b\u8a08\u6e2c\u3059\u308b\u6280\u8853\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u307e\u3059\uff0e\u86cd\u5149\u6027\u30ca\u30ce\u30c0\u30a4\u30e4\u30e2\u30f3\u30c9\u306f\uff0c\u5149\u9000\u8272\u3084\u5149\u70b9\u6ec5\u304c\u307b\u3068\u3093\u3069\u306a\u304f\uff0cpH\uff0c\u30a4\u30aa\u30f3\u6fc3\u5ea6\uff0c\u7c98\u6027\u306a\u3069\u306e\u5f71\u97ff\u3092\u53d7\u3051\u306b\u304f\u3044\u305f\u3081\uff0c\u8907\u96d1\u306a\u7d30\u80de\u5185\u74b0\u5883\u3067\u3082\u5b89\u5b9a\u306b\u50cd\u304f\u30ed\u30d0\u30b9\u30c8\u306a\u91cf\u5b50\u30bb\u30f3\u30b5\u3067\u3059\uff0e\u3055\u3089\u306b\uff0c\u86cd\u5149\u6027\u30ca\u30ce\u30c0\u30a4\u30e4\u30e2\u30f3\u30c9\u3092\u5149\u71b1\u5909\u63db\u6750\u6599\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\uff0c\u300c\u52a0\u71b1\u300d\u3068\u300c\u6e29\u5ea6\u8a08\u6e2c\u300d\u3092\u540c\u3058\u30ca\u30ce\u7c92\u5b50\u4e0a\u3067\u884c\u3046\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30bb\u30f3\u30b5\u306e\u958b\u767a\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\uff0e\u3053\u308c\u306b\u3088\u308a\uff0c\u7d30\u80de\u5185\u306e\u71b1\u4f1d\u5c0e\u3084\u5c40\u6240\u7684\u306a\u6e29\u5ea6\u5fdc\u7b54\u3092\u8abf\u3079\uff0c\u71b1\u304c\u751f\u547d\u73fe\u8c61\u306b\u3069\u306e\u3088\u3046\u306b\u95a2\u4e0e\u3059\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\uff0e\u3053\u306e\u3088\u3046\u306b\u5f53\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u30ca\u30ce\u7c92\u5b50\u306e\u6750\u6599\u8a2d\u8a08\uff0c\u8868\u9762\u5316\u5b66\u4fee\u98fe\uff0c\u5149\u8a08\u6e2c\uff0c\u7d30\u80de\u5b9f\u9a13\u3092\u7d44\u307f\u5408\u308f\u305b\uff0c\u7d30\u80de\u5185\u306e\u7269\u7406\u91cf\u3092\u5b9a\u91cf\u3059\u308b\u6280\u8853\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059\uff0e<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"382\" height=\"294\" src=\"http:\/\/sotoma-lab.com\/wp-content\/uploads\/2026\/02\/image-2.png\" alt=\"\" class=\"wp-image-34\" srcset=\"https:\/\/sotoma-lab.com\/wp-content\/uploads\/2026\/02\/image-2.png 382w, https:\/\/sotoma-lab.com\/wp-content\/uploads\/2026\/02\/image-2-300x231.png 300w\" sizes=\"auto, (max-width: 382px) 100vw, 382px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbS. Shimomura, Y. Nakane, H. Abe, Y. Miyake, T. Ohshima, Y. Yoshida, K. Maeda, T. Sugi, and S. Sotoma, \u201cDefect-Activated and Surface-Modified Hexagonal Boron Nitride Nanoparticles toward Intracellular Quantum Sensing,\u201d Nano Letters, 26, 3674\u20133680 (2026). <br>\u30fbT. Sekiguchi, S. Sotoma, and Y. Harada, \u201cFluorescent Nanodiamonds as a Robust Temperature Sensor Inside a Single Cell,\u201d Biophysics and Physicobiology, 15, 229\u2013234 (2018). <br>\u30fbS. Sotoma, C. Zhong, J. C. Y. Kah, H. Yamashita, T. Plakhotnik, Y. Harada, and M. Suzuki, \u201cIn Situ Measurements of Intracellular Thermal Conductivity Using Heater-Thermometer Hybrid Diamond Nanosensors,\u201d Science Advances, 7, eabd7888 (2021). <br>\u30fbS. Chuma, K. Kiyosue, T. Akiyama, M. Kinoshita, Y. Shimazaki, S. Uchiyama, S. Sotoma, K. Okabe, and Y. Harada, \u201cImplication of Thermal Signaling in Neuronal Differentiation Revealed by Manipulation and Measurement of Intracellular Temperature,\u201d Nature Communications, 15, 3473 (2024).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"nanozyme\">\uff14\uff09\u30ca\u30ce\u30b6\u30a4\u30e0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ca\u30ce\u30b6\u30a4\u30e0\u306f\uff0c\u30ca\u30ce\u7c92\u5b50\u304c\u793a\u3059\u9175\u7d20\u69d8\u6d3b\u6027\u3092\u5229\u7528\u3057\u305f\u4eba\u5de5\u89e6\u5a92\u6750\u6599\u3067\u3059\uff0e\u5929\u7136\u9175\u7d20\u306b\u6bd4\u3079\u3066\u9ad8\u3044\u5b89\u5b9a\u6027\u3084\u8010\u4e45\u6027\u3092\u6709\u3057\uff0c\u53cd\u5fdc\u6761\u4ef6\u306e\u5236\u5fa1\u3084\u6a5f\u80fd\u8a2d\u8a08\u304c\u5bb9\u6613\u3067\u3042\u308b\u3068\u3044\u3046\u7279\u9577\u304c\u3042\u308a\u307e\u3059\uff0e\u5f53\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u30ca\u30ce\u6750\u6599\u306e\u8868\u9762\u69cb\u9020\u3084\u5316\u5b66\u4fee\u98fe\u3092\u7cbe\u5bc6\u306b\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067\uff0c\u53cd\u5fdc\u9078\u629e\u6027\u3084\u6d3b\u6027\u3092\u8abf\u6574\u3057\uff0c\u7d30\u80de\u5185\u53cd\u5fdc\u306e\u5236\u5fa1\u3084\u30bb\u30f3\u30b7\u30f3\u30b0\u3068\u7d50\u3073\u3064\u3044\u305f\u65b0\u3057\u3044\u30ca\u30ce\u30b6\u30a4\u30e0\u6a5f\u80fd\u306e\u5275\u51fa\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\uff0e<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"304\" height=\"236\" src=\"http:\/\/sotoma-lab.com\/wp-content\/uploads\/2026\/02\/image-3.png\" alt=\"\" class=\"wp-image-35\" srcset=\"https:\/\/sotoma-lab.com\/wp-content\/uploads\/2026\/02\/image-3.png 304w, https:\/\/sotoma-lab.com\/wp-content\/uploads\/2026\/02\/image-3-300x233.png 300w\" sizes=\"auto, (max-width: 304px) 100vw, 304px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u7814\u7a76\u6982\u8981\u3000(Research overview) \u751f\u304d\u305f\u7d30\u80de\u306e\u7269\u7406\u5316\u5b66\u91cf\u3092\u89b3\u5bdf\u30fb\u8a08\u6e2c\u30fb\u64cd\u4f5c\u3059\u308b\u91cf\u5b50\u30bb\u30f3\u30b5\u306e\u958b\u767a\u3068\u5fdc\u7528\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002 \uff11\uff09\u30ca\u30ce\u7c92\u5b50\u306e\u8a2d\u8a08\u30fb\u8868\u9762\u5316\u5b66\u4fee\u98fe\u30fb\u30d0\u30a4\u30aa\u5fdc\u7528 \u30ca\u30ce\u7c92\u5b50\u306f\uff0c\u30b5\u30a4\u30ba\u304c\u6570 nm [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":38,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"sns_share_botton_hide":"","vkExUnit_sns_title":"","_vk_print_noindex":"","sitemap_hide":"","vkExUnit_sitemap":"","_veu_custom_css":"","veu_display_promotion_alert":"common","_exclude_from_list_pages":"","vkexunit_cta_each_option":"","vkExUnit_childPageIndex":"","vkExUnit_pageList_ancestor":"","vkExUnit_contact_enable":"","_lightning_design_setting":{"layout":"default"},"footnotes":""},"class_list":["post-31","page","type-page","status-publish","has-post-thumbnail","hentry"],"veu_head_title_object":{"title":"","add_site_title":""},"_links":{"self":[{"href":"https:\/\/sotoma-lab.com\/index.php?rest_route=\/wp\/v2\/pages\/31","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sotoma-lab.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sotoma-lab.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sotoma-lab.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/sotoma-lab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=31"}],"version-history":[{"count":16,"href":"https:\/\/sotoma-lab.com\/index.php?rest_route=\/wp\/v2\/pages\/31\/revisions"}],"predecessor-version":[{"id":242,"href":"https:\/\/sotoma-lab.com\/index.php?rest_route=\/wp\/v2\/pages\/31\/revisions\/242"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sotoma-lab.com\/index.php?rest_route=\/wp\/v2\/media\/38"}],"wp:attachment":[{"href":"https:\/\/sotoma-lab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=31"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}